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Using two separate drugs to shed weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err assisting caution and permit the FDA do its job and demand some investigation be done so your public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their own medications. Researchers discovered that participants investing in this drug to get a year, dropped excess weight within one month and have kept the extra weight off through the 56 weeks from the study. Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which are made up of many active ingredient, which can make them more potent and safer. Combo-pilling may be the newest fad or also the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular may be the fact that by right now there are not any long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug also can raise blood pressure level and heart rate, and must not be used in individuals with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients to the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. From a psychiatric point of view, evidence suggests that the ordinary neural mechanism for goal-directed behavior has become hijacked with the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object generates a stimulus along with the person engages in a "goal-directed behavioral response" that creates a "natural high"(Bostwick & Bucci, 2008).